Iordanidis Fotis, Hytiroglou Prodromos, Drevelegas Antonios, Kodonas Fotis, Ioannidis Ioannis, Nenopoulou Helen, Papadimitriou Constantine S
Department of Pathology, Aristotle University Medical School, 540 06 Thessaloniki, Greece.
Semin Liver Dis. 2002 Feb;22(1):97-102. doi: 10.1055/s-2002-23209.
A 25-year-old man without a prior history of liver disease presented with an 18-cm tumor of the right hepatic lobe, which was associated with multiple nodular lesions in the remaining parenchyma. The histologic and immunohistochemical features of the neoplasm were those of a poorly differentiated leiomyosarcoma with epithelioid features. The nodular lesions measured up to 4 cm in greatest dimension and had gross and microscopic features of focal nodular hyperplasia. This case suggests that multiple focal nodular hyperplasia may occasionally represent a parenchymal reaction to abnormal blood supply developing within the liver as a consequence of an enlarging malignant tumor.
一名既往无肝脏疾病史的25岁男性，出现一个18厘米的右肝叶肿瘤，其余肝实质内伴有多个结节性病变。该肿瘤的组织学和免疫组化特征为具有上皮样特征的低分化平滑肌肉瘤。结节性病变最大直径达4厘米，具有局灶性结节性增生的大体和显微镜特征。该病例提示，多个局灶性结节性增生偶尔可能代表肝脏内由于恶性肿瘤增大而出现的异常血供所引发的实质反应。
