确认使用激素替代疗法的绝经后女性心血管疾病、癌症及死亡的发生率

Incidence of cardiovascular disease, cancer and death in postmenopausal women affirming use of hormone replacement therapy.

作者信息

Hedblad Bo, Merlo Juan, Manjer Jonas, Engström Gunnar, Berglund Göran, Janzon Lars

机构信息

Department of Community Medicine, Lund University, Malmö University Hospital, Malmö, Sweden.

出版信息

Scand J Public Health. 2002;30(1):12-9.

PMID:11928828

Abstract

AIM

The goal of this study was to evaluate the incidence of myocardial infarction, cancer and death in relation to use of hormone replacement therapy (HRT).

METHODS

Nine years' follow up of an urban cohort of peri-/postmenopausal women was undertaken. Local and national registers were used for retrieval of events.

RESULTS

The incidence of myocardial infarction per 1.000 person-years in users and non-users was 0.61 (5/962) and 2.20 (92/4759) respectively, adjusted relative risk (RR) 0.37; 95% confidence interval 0.15-0.90. Rates of mortality from cardiovascular disease and cancer were 0.36 and 1.10, p= 0.058, and 2.60 and 2.09, p=0.360 respectively. In terms of all-cause mortality the adjusted RR was 1.02; 0.69-1.52, incidence of cancer 1.28; 1.01-1.64, breast cancer 1.52; 1.01-2.28 and endometrial cancer 3.61; 1.54-8.46.

CONCLUSIONS

Women affirming use of HRT had a lower incidence of myocardial infarction. Further studies are needed to assess whether the absence of effect on total mortality may be accounted for by an increased cancer risk.

摘要

目的

本研究旨在评估激素替代疗法（HRT）的使用与心肌梗死、癌症和死亡发生率之间的关系。

方法

对一组城市围绝经期/绝经后妇女进行了九年的随访。利用当地和国家登记处检索相关事件。

结果

使用者和非使用者每1000人年中心肌梗死的发生率分别为0.61（5/962）和2.20（92/4759），调整后的相对风险（RR）为0.37；95%置信区间为0.15 - 0.90。心血管疾病和癌症的死亡率分别为0.36和1.10，p = 0.058，以及2.60和2.09，p = 0.360。在全因死亡率方面，调整后的RR为1.02；0.69 - 1.52，癌症发生率为1.28；1.01 - 1.64，乳腺癌为1.52；1.01 - 2.28，子宫内膜癌为3.61；1.54 - 8.46。