Ma Q, Liu W, Wu L Y, Chao F H
Institute of Health and Environmental Medicine, Tianjin 300050.
Sheng Li Xue Bao. 2001 Aug;53(4):257-60.
The effects of excess glutamate on the survival rate of cultured hippocampal neurons, the population spike (PS) of CA1 area of hippocampal slices and the Ca(2+) current of hippocampal neurons were observed in rats. Decreased survival rate of hippocampal neurons in the presence of excess glutamate was partially reversed by 5-HT, which was in association with a less decrease of PS magnitudes. The Ca(2+) inward current induced by glutamate was significantly diminished in the presence of 5-HT. It is suggested that 5-HT can inhibit excess glutamate-induced neurotoxicity by suppressing the glutamate triggered calcium influx.
在大鼠中观察了过量谷氨酸对培养的海马神经元存活率、海马脑片CA1区群体峰电位（PS）以及海马神经元钙电流的影响。5-羟色胺可部分逆转过量谷氨酸存在时海马神经元存活率的降低，这与PS幅度的降低较少有关。在5-羟色胺存在的情况下，谷氨酸诱导的钙内向电流显著减小。提示5-羟色胺可通过抑制谷氨酸触发的钙内流来抑制过量谷氨酸诱导的神经毒性。
