[血清神经元特异性烯醇化酶检测在小细胞肺癌中的预后价值]
[The prognostic value of serum neuron specific enolase detection in small cell lung cancer].
作者信息
Jin B, Zhao L, Zhou C
机构信息
Department of Medicine, Shanghai Pneumology Hospital, Shanghai 200433, China.
出版信息
Zhonghua Jie He He Hu Xi Za Zhi. 2001 Dec;24(12):722-4.
OBJECTIVE
To evaluate the prognostic value of NSE detection in small cell lung cancer.
METHODS
144 unresectable small cell lung cancer patients were eligible in the retrospective study. NSE was analyzed before chemotherapy and 21 days after chemotherapy using ELISA method.
RESULTS
For D1-NSE, 98 (68.1%) were NSE positive and 46(31.9%) were NSE negative; for D21-NSE, 57(39.6%) were NSE positive and 87 (60.4%) were NSE negative. In univariate analysis, both D1-NSE and D21-NSE have prognostic significance. But in multivariate analysis only D21-NSE is an independent prognostic factor.
CONCLUSION
D21-NSE in small cell lung cancer is an independent prognostic factor and may be proposed for use in the clinic and research.
目的
评估神经元特异性烯醇化酶（NSE）检测在小细胞肺癌中的预后价值。
方法
144例无法切除的小细胞肺癌患者纳入本回顾性研究。化疗前及化疗21天后采用酶联免疫吸附测定（ELISA）法分析NSE。
结果
对于化疗前NSE（D1-NSE），98例（68.1%）NSE阳性，46例（31.9%）NSE阴性；对于化疗21天后NSE（D21-NSE），57例（39.6%）NSE阳性，87例（60.4%）NSE阴性。单因素分析中，D1-NSE和D21-NSE均具有预后意义。但多因素分析中只有D21-NSE是独立预后因素。
结论
小细胞肺癌中的D21-NSE是独立预后因素，可推荐用于临床和研究。
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