细胞外人类免疫缺陷病毒1型Tat蛋白的血管生成作用及其在艾滋病相关卡波西肉瘤发病机制中的作用。
Angiogenic effects of extracellular human immunodeficiency virus type 1 Tat protein and its role in the pathogenesis of AIDS-associated Kaposi's sarcoma.
作者信息
Barillari Giovanni, Ensoli Barbara
机构信息
Laboratory of Virology, Istituto Superiore di Sanità, 00161 Rome, Italy.
出版信息
Clin Microbiol Rev. 2002 Apr;15(2):310-26. doi: 10.1128/CMR.15.2.310-326.2002.
Abstract
The Tat protein of human immunodeficiency virus (HIV) type 1 is a transactivator of viral gene expression that is required for virus replication and spread. Moreover, Tat is released by acutely HIV-infected cells via a leaderless secretory pathway and in a biologically active form that exerts effects on both HIV-infected and uninfected cells from different organs and systems. This review focuses on the activities of extracellular Tat protein on endothelial cells, on angiogenesis, and on the pathogenesis of AIDS-associated angioproliferative diseases such as Kaposi's sarcoma. In particular, we discuss results from different groups indicating that Tat mimics the proangiogenic activities of extracellular matrix molecules and that it enhances the effects of angiogenic factors.
摘要
人类免疫缺陷病毒1型（HIV-1）的反式激活因子（Tat）蛋白是病毒基因表达的反式激活剂，是病毒复制和传播所必需的。此外，Tat由急性HIV感染的细胞通过无信号肽分泌途径以生物活性形式释放，对来自不同器官和系统的HIV感染和未感染细胞均有影响。本综述重点关注细胞外Tat蛋白在内皮细胞、血管生成以及艾滋病相关血管增殖性疾病（如卡波西肉瘤）发病机制中的作用。特别是，我们讨论了不同研究小组的结果，这些结果表明Tat模拟细胞外基质分子的促血管生成活性，并增强血管生成因子的作用。
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