Reed J E, Allen W E, Dohrmann G J
Spine (Phila Pa 1976). 1979 Sep-Oct;4(5):391-7. doi: 10.1097/00007632-197909000-00001.
The effects of mannitol on the spinal cord blood flow patterns in experimental traumatic paraplegia were correlated with microangiographic and electrophysiologic studies. At 1 hour following a therapeutic dose of mannitol (3 g/kg), an improved fluorescent intramedullary vascular pattern was detected among the mannitol-treated animals relative to those that were not treated. Within 4 hours, perfusion of many areas of the lateral white matter of the spinal cord often approximated normal in the mannitol-treated group. This pattern of perfusion was in striking contrast to that seen in the spinal cord of untreated animals, which displayed an almost total lack of fluorescing vessels at this later time. These findings correlated with an increased vascular caliber as revealed by microangiography and were postulated to be the result of a decrease in vasospasm and an expanded intramedullary blood volume following the administration of mannitol. Although mannitol therapy did not reverse the loss of the cortical evoked response observed during the 4-hour interval studied, the observation of improved blood flow patterns in the white matter is encouraging and warrants further study.
将甘露醇对实验性创伤性截瘫脊髓血流模式的影响与微血管造影和电生理研究进行了关联。在给予治疗剂量的甘露醇（3克/千克）1小时后，相对于未治疗的动物，在接受甘露醇治疗的动物中检测到荧光髓内血管模式有所改善。在4小时内，甘露醇治疗组脊髓外侧白质的许多区域的灌注常常接近正常。这种灌注模式与未治疗动物脊髓中所见的模式形成鲜明对比，未治疗动物的脊髓在这个较晚时间几乎完全缺乏荧光血管。这些发现与微血管造影显示的血管口径增加相关，并推测是甘露醇给药后血管痉挛减少和髓内血容量增加的结果。尽管甘露醇治疗并未逆转在所研究的4小时间隔内观察到的皮质诱发反应的丧失，但白质血流模式改善的观察结果令人鼓舞，值得进一步研究。
