Harpf Christoph, Dabernig Jörg, Humpel Christian
University Clinic for Plastic and Reconstructive Surgery, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria.
Muscle Nerve. 2002 Apr;25(4):612-5. doi: 10.1002/mus.10103.
Immunhistochemistry of 10 traumatic human peripheral nerve neuromas and 5 normal digital nerves revealed a high immunoreactivity for the nerve growth factor (NGF) receptors p75 and trkA and the glial cell line-derived neurotrophic factor (GDNF) receptor GFRalpha-1. Semiquantitative image analysis showed a significantly increased trkA immunoreactivity in the neuroma group. The presence of the receptors may provide a way to influence therapy of peripheral nerve neuroma by administration of neurotrophins or other substances with binding sites similar to those of a neurotrophic factor.
对10例创伤性人类周围神经神经瘤和5条正常指神经进行免疫组织化学检测，结果显示神经生长因子（NGF）受体p75和trkA以及胶质细胞系源性神经营养因子（GDNF）受体GFRalpha-1具有高免疫反应性。半定量图像分析显示神经瘤组trkA免疫反应性显著增加。这些受体的存在可能为通过给予神经营养因子或其他具有与神经营养因子相似结合位点的物质来影响周围神经神经瘤的治疗提供一种方法。
