[Syndecan-1（CD138）：浆细胞肿瘤的免疫组化标志物]
[Syndecan-1 (CD138): an immunohistochemical marker of plasma cell tumors].
作者信息
Fakan F, Boudová L, Hejda C
机构信息
Siklův patologicko-anatomický ústav Lékarské fakulty UK a Fakultní nemocnice, Plzen.
出版信息
Cesk Patol. 2002 Jan;38(1):33-6.
The immunohistochemical detection of syndecan-1 (belonging to the cluster CD138) is a sensitive and reliable method for identifying normal and neoplastic plasma cells. It may be used in paraffin-embedded bone marrow specimens, as well as in extramedullary tumours of unknown origin. The three anaplastic tumours reported by us in the lymph node, the gingiva, and pleura were negative for other markers, but the syndecan-1 positivity elucidated their plasmocytic histogenesis.
检测syndecan-1（属于CD138簇）的免疫组织化学方法是鉴定正常和肿瘤性浆细胞的一种敏感且可靠的方法。它可用于石蜡包埋的骨髓标本，以及来源不明的髓外肿瘤。我们报告的发生于淋巴结、牙龈和胸膜的三例间变性肿瘤对其他标志物呈阴性，但syndecan-1阳性揭示了它们的浆细胞组织发生。
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