母体血清和羊水中的细胞间黏附分子-1作为子痫前期和胎儿生长受限的早期标志物。
ICAM-1 in maternal serum and amniotic fluid as an early marker of preeclampsia and IUGR.
作者信息
Baviera Giovanni, D'Anna Rosario, Corrado Francesco, Ruello Antonella, Buemi Michele, Jasonni Valerio Maria
机构信息
Departments of Gynecology and Internal Medicine, University of Messina, Messina, Italy.
出版信息
J Reprod Med. 2002 Mar;47(3):191-3.
OBJECTIVE
To determine if plasma and amniotic fluid levels of intercellular adhesion molecule-1 (ICAM-1) at 16 weeks' gestation could be predictive of preeclampsia or intrauterine growth retardation (IUGR).
STUDY DESIGN
A retrospective analysis was undertaken in 44 serum samples stored for Down's syndrome screening at 16 weeks' gestation and 44 amniotic fluid samples obtained by midtrimester amniocentesis.
RESULTS
No significant difference was found between women who subsequently developed preeclampsia or IUGR and the control group.
CONCLUSION
This study failed to demonstrate that ICAM-1 may be an early serum marker of preeclampsia or an amniotic fluid marker of IUGR.
目的
确定妊娠16周时血浆和羊水细胞间黏附分子-1（ICAM-1）水平是否可预测子痫前期或胎儿宫内生长受限（IUGR）。
研究设计
对妊娠16周时为进行唐氏综合征筛查而储存的44份血清样本以及孕中期羊膜腔穿刺获取的44份羊水样本进行回顾性分析。
结果
随后发生子痫前期或IUGR的女性与对照组之间未发现显著差异。
结论
本研究未能证明ICAM-1可能是子痫前期的早期血清标志物或IUGR的羊水标志物。
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