Nicolie B, Bonneau J C, Le Sellin J, Gay G, Leclere J M, Drouet M
Laboratoire d'immuno-allergologie, CHU-49033 Angers, France.
Allerg Immunol (Paris). 2002 Feb;34(2):47-50.
Delayed hypersensitivity to heparins and heparinoïd is a problem for prophylaxis of thrombo embolic diseases. The hirudins did not seem to have any cross-reactivity with the two others groups of anticoagulants. We present two clinical cases of delayed type reactions to heparins and heparinoïd and we reviewed the literature about adverse reactions to low molecular weight heparins and the alternative possibilities.
对肝素和类肝素的迟发型超敏反应是血栓栓塞性疾病预防中的一个问题。水蛭素似乎与其他两类抗凝剂没有任何交叉反应。我们报告了两例对肝素和类肝素的迟发型反应的临床病例，并回顾了关于低分子量肝素不良反应及替代可能性的文献。
