Hannu T, Mattila L, Rautelin H, Pelkonen P, Lahdenne P, Siitonen A, Leirisalo-Repo M
Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Finland.
Rheumatology (Oxford). 2002 Mar;41(3):312-8. doi: 10.1093/rheumatology/41.3.312.
To study the incidence and clinical picture of Campylobacter-associated reactive arthritis (ReA) and other reactive musculoskeletal symptoms in the population.
A questionnaire on enteric and extraintestinal, including specifically musculoskeletal, symptoms was sent to 870 consecutive patients with Campylobacter-positive stool culture and 1440 matched controls. Analysis of self-reported musculoskeletal symptoms with clinical examination was performed.
Forty-five of the patients (7%) had ReA and eight (1%) had reactive tendinitis, enthesopathy or bursitis. No child had ReA. The arthritis was oligo- or polyarticular, and, in most cases, mild. HLA-B27 was positive in 14% of ReA patients. Of the 45 ReA patients, 37 had C. jejuni and 8 had C. coli infection. No controls had ReA.
ReA is common following Campylobacter infection, with an annual incidence of 4.3 per 100000. At the population level, acute ReA is mild, more frequent in adults, and not associated with HLA-B27. Besides C. jejuni, C. coli can trigger ReA.
研究人群中弯曲杆菌相关反应性关节炎（ReA）及其他反应性肌肉骨骼症状的发病率和临床表现。
向870例连续的弯曲杆菌粪便培养阳性患者及1440例匹配对照发送一份关于肠道及肠道外症状（特别是肌肉骨骼症状）的问卷。对自我报告的肌肉骨骼症状进行临床检查分析。
45例患者（7%）患有ReA，8例（1%）患有反应性肌腱炎、附着点病或滑囊炎。无儿童患ReA。关节炎为少关节或多关节型，多数情况下症状较轻。14%的ReA患者HLA - B27呈阳性。45例ReA患者中，37例感染空肠弯曲菌，8例感染结肠弯曲菌。对照中无ReA患者。
弯曲杆菌感染后ReA常见，年发病率为每10万人4.3例。在人群层面，急性ReA症状较轻，在成年人中更常见，且与HLA - B27无关。除空肠弯曲菌外，结肠弯曲菌也可引发ReA。
