Judkins Alexander R, Forman Mark S, Uryu Kunihiro, Hinkle David A, Asbury Arthur K, Lee Virginia M-Y, Trojanowski John Q
Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Acta Neuropathol. 2002 May;103(5):526-30. doi: 10.1007/s00401-001-0483-7. Epub 2002 Jan 17.
Parkinson's disease (PD) and progressive supranuclear palsy (PSP) are distinct neurodegenerative disorders. We describe an 81-year-old woman with 3 years of progressive gait unsteadiness, frequent falls, and mild cognitive dysfunction, all considered clinically to be an early fronto-temporal neurodegenerative disorder. She died of an acute myocardial infarction. Examination of her brain revealed alpha-synuclein- and tau-positive inclusions diagnostic of PD and PSP. Immunoelectron microscopy and Western blot analysis confirmed combined PD/PSP. This case provides strategies for the reliable molecular validation of concomitant PD and PSP, and demonstrates the utility of these techniques in patients with atypical clinical presentations.
帕金森病（PD）和进行性核上性麻痹（PSP）是不同的神经退行性疾病。我们描述了一位81岁女性，她有3年进行性步态不稳、频繁跌倒及轻度认知功能障碍，临床上均被认为是早期额颞叶神经退行性疾病。她死于急性心肌梗死。对其脑部检查发现有诊断为PD和PSP的α-突触核蛋白和tau阳性包涵体。免疫电子显微镜和蛋白质印迹分析证实为合并的PD/PSP。该病例为同时存在的PD和PSP的可靠分子验证提供了策略，并证明了这些技术在非典型临床表现患者中的实用性。
