Cohen J
Dept of Infectious Diseases & Microbiology, Imperial College School of Medicine, Hammersmith Hospital, London, England, UK.
J Chemother. 2001 Nov;13 Spec No 1(1):153-8. doi: 10.1179/joc.2001.13.Supplement-2.153.
Sepsis is the systemic response to infection, and is caused by gram positive and gram negative bacteria in approximately equal numbers. In recent years it has become increasingly clear that there are significant differences between sepsis caused by gram positive and gram negative infections, both in the microbial components that initiate the injury, and the host responses that follow it. These differences will assume greater importance in developing targeted therapeutic interventions to severe sepsis.
脓毒症是机体对感染的全身性反应，由革兰氏阳性菌和革兰氏阴性菌引起，二者数量大致相等。近年来越来越清楚的是，革兰氏阳性菌感染和革兰氏阴性菌感染所致脓毒症在引发损伤的微生物成分以及随后的宿主反应方面均存在显著差异。这些差异在制定针对严重脓毒症的靶向治疗干预措施时将变得更加重要。
