Chin Anthony, O'Conner Linh Nguyen, Radhakrishnan Jayant, Fornell Linda, John Eunice
Department of Surgery and Pediatrics, Division of Pediatric Surgery, University of Illinois College of Medicine at Chicago, USA.
Biol Neonate. 2002;81(3):196-202. doi: 10.1159/000051534.
In this study, we observed the effects of moderate and high doses of dopamine on the renal functions of neonatal piglets during endotoxic shock. We found that fluid therapy alone was better at maintaining cardiac index and preventing elevation of systemic vascular resistance, than dopamine at 10 and at 20 microg/kg/min. Furthermore, urine output and glomerular filtration rate were reduced by dopamine. Following endotoxin administration dopamine decreased SVR and maintained a CI better than fluid alone. However, in spite of a better CI, greater deterioration in renal functions occurred in the dopamine groups as compared to the fluid group.
在本研究中，我们观察了中、高剂量多巴胺对内毒素休克新生仔猪肾功能的影响。我们发现，单纯液体疗法在维持心指数和防止全身血管阻力升高方面，比10和20微克/千克/分钟剂量的多巴胺效果更好。此外，多巴胺会降低尿量和肾小球滤过率。给予内毒素后，多巴胺降低了全身血管阻力，且在心指数维持方面比单纯液体疗法更好。然而，尽管多巴胺组的心指数更好，但与单纯液体组相比，其肾功能恶化更为严重。
