Schalow Giselher
Department of Neurology and Rehabilitation, University Hospital Tampere, PB 2000, 33521 Tampere, Finland.
Electromyogr Clin Neurophysiol. 2002 Mar;42(2):85-104.
Based on measurements of relative phase and frequency coordination of time-space distributed firing of single neurons and neuron assemblies in the human nervous system, the concept of coordination dynamics to describe the integrative functions of the human central nervous system (CNS) and the finding of neurogenesis in the human CNS, the coordination dynamic therapy has been developed with which it is possible to repair the lesioned or malfunctioning human CNS. With the developed coordination dynamic recording method the organization (the coordination dynamics) of the CNS can be measured on-line non-invasively. By measuring the present coordination dynamics at different times with ongoing coordination dynamic therapy when exercising on a special coordination dynamic therapy device, the progress in re-organization and repair of the lesioned CNS can be quantified. In this paper it is reported that in 8 patients following stroke the lesioned CNS could partly be repaired by coordination dynamic therapy. The repair was quantified by the improvement of walking, hand function and the direct measurement of CNS organization (the coordination dynamics). In 4 patients the improvement of CNS organization (coordinations dynamics) was 70 +/- 14% within 3 months of therapy. In a patient where the intensive coordination dynamic therapy (at least 4 hours therapy with more than 15,000 coordinated movements per day) lasted longer than one year, also the difficult repairable hand functions could substantially be improved. It is shown that in the healthy CNS of the author the coordination dynamics improved in the short-term memory by 20% within 10 min and in a stroke patient by 70% within 30 min, when exercising on the special coordination dynamic therapy device. As in other learning therapies (school) it is believed, that by repeated learning of movements, vegetative and higher mental functions in the short-term memory, the learned CNS functions will also go into the long-term memory, which means the CNS has been reorganized. Improvements in the short-term memory are used to motivate the patient to perform a therapy.
基于对人类神经系统中单个神经元和神经元集合时空分布式放电的相对相位和频率协调性的测量、描述人类中枢神经系统（CNS）整合功能的协调动力学概念以及人类CNS中神经发生的发现，开发了协调动态疗法，通过该疗法可以修复受损或功能失调的人类CNS。利用已开发的协调动态记录方法，可以在线非侵入性地测量CNS的组织（协调动力学）。通过在特殊的协调动态治疗设备上进行锻炼时，在进行协调动态治疗的不同时间测量当前的协调动力学，可以量化受损CNS的重组和修复进展。本文报道，8例中风患者的受损CNS通过协调动态疗法可部分修复。通过步行、手部功能的改善以及对CNS组织（协调动力学）的直接测量来量化修复情况。4例患者在治疗3个月内CNS组织（协调动力学）的改善为70±14%。在1例接受强化协调动态治疗（每天至少4小时治疗，协调动作超过15000次）持续时间超过1年的患者中，难以修复的手部功能也得到了显著改善。结果表明，当在特殊的协调动态治疗设备上进行锻炼时，作者健康的CNS在短期记忆中，10分钟内协调动力学改善了20%，中风患者在30分钟内改善了70%。与其他学习疗法（学校）一样，人们认为，通过重复学习运动、短期记忆中的植物性和高级心理功能，所学的CNS功能也将进入长期记忆，这意味着CNS已经重组。短期记忆的改善被用来激励患者进行治疗。
