Wang C, Peng S, Zhang X, Qiu X
College of Phamacutical Sciences, Beijing Medical University, Beijing 100083.
Yao Xue Xue Bao. 1998;33(2):111-6.
Hydrocortisone was coupled with urotoxin tripeptide UTP-A, UTP-B and UTP-C respectively yielding 4 linkers. Their bioactivities such as prolongation of heterotopic transplanted cardiac tissue survival, inhibitory effects on phagocytosis of mouse peritoneal macrophages and the influence on Con A induced proliferation of spleen lymphocytes of mouse were observed. Compared with UTP-A, UTP-B, UTP-C or hydrocortisone the linkers were more potent immunosuppressants. The results suggest that the linker of steroid-peptide may simulate the permissive action.
氢化可的松分别与尿毒素三肽UTP - A、UTP - B和UTP - C偶联，得到4种连接物。观察了它们的生物活性，如延长异位移植心脏组织的存活时间、对小鼠腹腔巨噬细胞吞噬作用的抑制作用以及对小鼠脾脏淋巴细胞Con A诱导增殖的影响。与UTP - A、UTP - B、UTP - C或氢化可的松相比，这些连接物是更强效的免疫抑制剂。结果表明，类固醇 - 肽连接物可能模拟了允许作用。
