胃复安未能影响促黄体生成素、促卵泡激素和促甲状腺激素的分泌或它们对释放激素的反应。

Failure of metoclopramide to influence LH, FSH and TSH secretion or their responses to releasing hormones.

作者信息

Spitz I M, Trestian S, Cohen H, Arnon N, LeRoith D

出版信息

Acta Endocrinol (Copenh). 1979 Dec;92(4):640-7. doi: 10.1530/acta.0.0920640.

DOI:10.1530/acta.0.0920640

Abstract

Intravenous metoclopramide (MET) (10 mg) induced a brisk PRL response with a mean +/- SEM peak of 85.3 +/- 7.7 ng/ml maximal at 30 min. L-Dopa, but not atropine pre-treatment, attenuated the prolactin (PRL) response to MET. This indicates that the antidopaminergic properties of MET mediate PRL secretion. MET did not influence basal levels of TSH, LH or FSH. Neither did it affect their response to the respective releasing of hormones. Our results indicate that dopaminergic blockade induced by iv MET, does not influence the secretion of the pituitary glycoprotein hormones.

摘要

静脉注射甲氧氯普胺（MET）（10毫克）可引起催乳素（PRL）迅速反应，平均±标准误峰值为85.3±7.7纳克/毫升，在30分钟时达到最大值。左旋多巴可减弱对MET的催乳素（PRL）反应，但阿托品预处理则无此作用。这表明MET的抗多巴胺能特性介导了PRL分泌。MET不影响促甲状腺激素（TSH）、促黄体生成素（LH）或促卵泡生成素（FSH）的基础水平，也不影响它们对各自释放激素的反应。我们的结果表明，静脉注射MET引起的多巴胺能阻断不影响垂体糖蛋白激素的分泌。

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