耐甲氧西林金黄色葡萄球菌对万古霉素敏感性的变化

[The change in sensitivity of methicillin-resistant Staphylococcus aureus to vancomycin].

作者信息

Ma Yue, Chen Hongbo, Yao Lei, Li Jingyun, Zhang Li, Hu Changqin, Jin Shaohong

机构信息

Division of Antibiotics, National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China.

出版信息

Zhonghua Nei Ke Za Zhi. 2002 Jan;41(1):31-3.

PMID:11940294

Abstract

OBJECTIVE

To determine the shift of susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) isolates to vancomycin in recent years.

METHODS

Antimicrobial susceptibility was determined by disk diffusion test (K-B method). The t-test was used to compare the mean diameters of zone of inhibition.

RESULTS

The clinical isolates of MRSA from 1994 to 2000 were 218, 187, 292, 237, 351, 886 and 652 in number respectively. The mean diameters (mm) of the inhibition zone of MRSA isolates each year were 19.9, 19.1, 18.6, 17.4, 18.4, 18.2 and 17.8. Comparison of the diameters of the inhibition zone of MRSA isolates (K-B method) showed that the mean diameter of the inhibition zone from the 652 MRSA isolates in 2000 was much less than that of the 218 MRSA isolates in 1994 and the difference was significant (P < 0.001). The resistant rates to chloramphenicol, ciprofloxacin, erythromycin, gentamicin, tetracycline and trimethoprim/sulfamethoxazole were 44.0%, 73.7%, 89.1%, 65.7%, 61.0% and 67.0%.

CONCLUSION

Our observation demonstrated that the susceptibility of MRSA to vancomycin gradually decreased from 1994 to 2000. It is important to monitor the antimicrobial susceptibility of Staphylococcus aureus to vancomycin.

摘要

目的

确定近年来耐甲氧西林金黄色葡萄球菌（MRSA）分离株对万古霉素敏感性的变化。

方法

采用纸片扩散法（K-B法）测定抗菌药物敏感性。用t检验比较抑菌圈平均直径。

结果

1994年至2000年MRSA临床分离株数量分别为218株、187株、292株、237株、351株、886株和652株。每年MRSA分离株抑菌圈的平均直径（mm）分别为19.9、19.1、18.6、17.4、18.4、18.2和17.8。对MRSA分离株（K-B法）抑菌圈直径的比较显示，2000年652株MRSA分离株的抑菌圈平均直径远小于1994年218株MRSA分离株的抑菌圈平均直径，差异有统计学意义（P<0.001）。对氯霉素、环丙沙星、红霉素、庆大霉素、四环素和复方新诺明的耐药率分别为44.0%、73.7%、89.1%、65.7%、61.0%和67.0%。