L'Allemain Gilles
UMR 6543, Institut de signalisation, de biologie du développement et cancer, parc Valrose, 06108 Nice Cedex 2.
Bull Cancer. 2002 Mar;89(3):257-60.
The vascular endothelial growth factors (VEGF) plays major roles during tumor development. VEGF expression is regulated by the transcription factor HIF (hypoxia inducible factor) which is very sensitive to oxygene variations. We will show here that HIF1alpha is today a good prognostic and diagnostic marker for an increasing number of cancers from various origins. Furthermore, the reduction of the expression or the activity of HIF1alpha impairs tumour angiogenesis and subsequently growth. Altogether, these results suggest that HIF1alpha could be an interesting target in cancer therapy.
血管内皮生长因子（VEGF）在肿瘤发展过程中发挥着主要作用。VEGF的表达受转录因子HIF（缺氧诱导因子）调控，HIF对氧含量变化非常敏感。我们将在此表明，如今HIF1α对于越来越多源自各种组织的癌症而言是一种良好的预后和诊断标志物。此外，HIF1α表达或活性的降低会损害肿瘤血管生成，进而抑制肿瘤生长。总之，这些结果表明HIF1α可能是癌症治疗中一个值得关注的靶点。
