Girmens J F, Fajnkuchen F, Badelon I, Chaine G
Service d'ophtalmologie, Hôpital Avicenne, 125 avenue de Stalingrad, 93009 Bobigny Cedex.
J Fr Ophtalmol. 2002 Mar;25(3):303-7.
Peripheral retinal neovascularization occurs in approximately 10% of cases of sarcoidosis. Its pathogenesis is unknown, but it probably results from retinal ischemia and/or inflammation. In cases of peripheral retinal neovascularization associated with sarcoidosis, sickle cell disease should be considered, even if sarcoidosis is histologically proved: new vessels seen in sickle cell disease and sarcoidosis may have a very similar pattern. We present two cases with histologically proven sarcoidosis who developed peripheral neovascularization: the first one had no associated disease and new vessels were likely to be related to sarcoidosis; in the second case, hemoglobin electrophoresis revealed hemoglobin SC, and provided diagnosis of sickle cell hemoglobinopathy.
周边视网膜新生血管形成约发生于10%的结节病病例中。其发病机制尚不清楚，但可能是由视网膜缺血和/或炎症引起的。在与结节病相关的周边视网膜新生血管形成病例中，即使结节病已通过组织学证实，也应考虑镰状细胞病：镰状细胞病和结节病中所见的新生血管可能具有非常相似的形态。我们报告两例经组织学证实为结节病且发生周边新生血管形成的病例：第一例无相关疾病，新生血管可能与结节病有关；在第二例中，血红蛋白电泳显示为血红蛋白SC，从而确诊为镰状细胞血红蛋白病。
