拉米夫定治疗早期乙型肝炎病毒的亚型依赖性反应。
Subtype-dependent response of hepatitis B virus during the early phase of lamivudine treatment.
作者信息
Zöllner Bernhard, Petersen Jörg, Schäfer Peter, Schröter Matthias, Laufs Rainer, Sterneck Martina, Feucht Heinz-Hubert
机构信息
Institute for Medical Microbiology and Immunology, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany.
出版信息
Clin Infect Dis. 2002 May 1;34(9):1273-7. doi: 10.1086/339959. Epub 2002 Apr 2.
We conducted a 12-month longitudinal investigation of the subtype-dependent response of hepatitis B virus (HBV) to lamivudine treatment in 43 consecutive patients with chronic hepatitis B. HBV subtype ayw appears to respond better to lamivudine monotherapy than does HBV subtype adw (P=.005). This might be the reason for the lower incidence of lamivudine-resistant strains observed in persons infected with HBV subtype ayw during follow-up.
我们对43例连续的慢性乙型肝炎患者进行了一项为期12个月的纵向研究，以观察乙肝病毒（HBV）不同亚型对拉米夫定治疗的反应。HBV ayw亚型对拉米夫定单药治疗的反应似乎优于adw亚型（P = 0.005）。这可能是在随访期间观察到感染HBV ayw亚型的患者中拉米夫定耐药株发生率较低的原因。
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