Shi Jingyi, Chen Saijuan
Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P. R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Apr;19(2):156-8.
With the development of the research in human genomics, it is well known that genetic polymorphisms(mainly single nucleotide polymorphisms) of the genes encoding drug-metabolizing enzymes, transporters, receptors and other drug target proteins are relative to interindividual differences in the efficacy and toxicity of many medications. On the basis of functional genomics and molecular pharmacology, pharmacogenomics is elucidating the inherited nature of these differences in drug response mainly by means of analyzing the genetic variations of DNA and monitoring the gene expression pattern. It can not only improve disease diagnosis and predict the potential drug response but also speed up drug discovery and its development which will be instructive for clinical drug therapy ultimately.
随着人类基因组学研究的发展，众所周知，编码药物代谢酶、转运体、受体和其他药物靶蛋白的基因的遗传多态性（主要是单核苷酸多态性）与许多药物疗效和毒性的个体差异有关。基于功能基因组学和分子药理学，药物基因组学主要通过分析DNA的遗传变异和监测基因表达模式来阐明这些药物反应差异的遗传本质。它不仅可以改善疾病诊断和预测潜在的药物反应，还可以加速药物发现及其开发，最终将对临床药物治疗具有指导意义。
