Dobrowolski Z F, Jaszczynski J, Drewniak T, Habrat W, Kusionowicz J
Department and Clinic of Urology, Collegium Medicum, Jagiellonian University, Cracow, Poland.
BJU Int. 2002 Apr;89(6):614-5. doi: 10.1046/j.1464-410x.2002.02695.x.
To assess whether organ-confined prostate cancer not detected on routine transrectal ultrasonography (TRUS) can be detected using three-dimensional (3-D) power Doppler methods.
A preliminary trial of the use of TRUS with 3-D power Doppler image reconstruction was conducted in 116 patients being evaluated for lower urinary tract symptoms. Using a microbubble enhancing agent, an adequate horizontal plane allowed the simultaneous visualization and assessment of the symmetry of echogenicity and vascularization of the peripheral area of both prostate lobes, which is not possible in standard TRUS. The peripheral zone vascular asymmetry in the horizontal plane was also assessed retrospectively in those patients with pT2a,b prostate carcinoma.
Stage pT2a,b prostate carcinoma was confirmed in 26 patients; in this group, two independent investigators confirmed the vascular asymmetry between the left and right peripheral zone, in the horizontal plane, in 22 patients, giving a sensitivity of 85%.
Vascular asymmetry allows guided biopsy in lesions that are invisible using standard TRUS. Microbubble agents are an effective method of increasing the acoustic signals from small vessels of the prostate.
评估使用三维（3-D）能量多普勒方法能否检测出常规经直肠超声检查（TRUS）未发现的器官局限性前列腺癌。
对116例因下尿路症状接受评估的患者进行了一项使用TRUS联合三维能量多普勒图像重建的初步试验。使用微泡增强剂后，一个合适的水平面可同时显示并评估双侧前列腺叶外周区域的回声性和血管化的对称性，而这在标准TRUS中是无法实现的。还对那些患有pT2a、b期前列腺癌的患者的水平面外周区血管不对称性进行了回顾性评估。
26例患者确诊为pT2a、b期前列腺癌；在该组中，两名独立研究者证实，22例患者在水平面左右外周区存在血管不对称，敏感性为85%。
血管不对称性有助于对标准TRUS无法发现的病变进行引导活检。微泡剂是增强来自前列腺小血管声学信号的有效方法。
