肺炎克雷伯菌中吲哚产生与抗生素敏感性的关系。 （注：原文中“Klebsiella bacillus”表述有误，应为“Klebsiella pneumoniae”，即肺炎克雷伯菌）
Relationship of indole production and antibiotic susceptibility in the Klebsiella bacillus.
作者信息
Klein D, Spindler J A, Matsen J M
出版信息
J Clin Microbiol. 1975 Nov;2(5):425-9. doi: 10.1128/jcm.2.5.425-429.1975.
Of 2,442 Klebsiella strains isolated from clinical specimens at the University of Minnesota hospitals, 18.3% were found to be indole positive. A randomly selected equal number of indole-positive and indole-negative control isolates, characterized by 27 biochemical tests and by serotyping against 72 antisera, were tested against 14 antibiotics. The results indicated a greater incidence of multiple drug resistance among the indole-negative strains among those that produced indole. The organisms in the former group, in comparison to their indole-positive counterparts, were significantly more resistant to nitrofurantoin, tetracycline, chloramphenicol, neomycin, streptomycin, nalidixic acid, and kanamycin. Both groups of organisms were similar in their degree of resistance to ampicillin, carbenicillin, cephalothin, sulfisoxazole, colistimethate, polymyxin B, and gentamicin. The biochemical properties of the two indole groups were essentially identical. Correlation between serotype and multidrug resistance was inapparent.
在明尼苏达大学医院从临床标本中分离出的2442株克雷伯菌中，发现18.3%为吲哚阳性。随机挑选数量相等的吲哚阳性和吲哚阴性对照菌株，通过27项生化试验和针对72种抗血清进行血清分型进行鉴定，然后用14种抗生素进行测试。结果表明，在产生吲哚的菌株中，吲哚阴性菌株的多重耐药发生率更高。与吲哚阳性对应菌株相比，前一组菌株对呋喃妥因、四环素、氯霉素、新霉素、链霉素、萘啶酸和卡那霉素的耐药性明显更强。两组菌株对氨苄西林、羧苄西林、头孢噻吩、磺胺异恶唑、黏菌素甲磺酸钠、多黏菌素B和庆大霉素的耐药程度相似。两个吲哚组的生化特性基本相同。血清型与多重耐药之间的相关性不明显。
Zotero 插件