Morita T, Shimada A, Ishibashi T, Kimura K, Haritani M, Umemura T
Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Minami 4-101, Tottori-shi, Koyama-cho, Tottori 680-8553, Japan.
J Comp Pathol. 2002 Feb-Apr;126(2-3):212-5. doi: 10.1053/jcpa.2001.0523.
This report describes a novel spongiform change in the brain stem nuclei of a 9-month-old mixed breed kitten with neurological signs. Histologically, vacuoles were found in perineuronal spaces and neuropil, with mild to moderate astrocytosis in the brain stem nuclei. Vacuoles were not observed in the cytoplasm of neurons and no evidence of neuronal loss was found. Ultrastructurally, there were intramyelinic vacuoles with separation of lamellae at intraperiod lines and larger spaces formed by coalescence of ruptured vacuoles. Immunohistochemically, abnormal accumulation of prion protein (PrP) was not detected in the brain stem lesions. This is, to our knowledge, the first report of a feline spongiform change localized in the brain stem nuclei.
本报告描述了一只9个月大出现神经症状的混种小猫脑干核中一种新的海绵状变化。组织学上，在神经元周围间隙和神经纤维网中发现空泡，脑干核中有轻度至中度星形胶质细胞增生。未在神经元细胞质中观察到空泡，也未发现神经元丢失的证据。超微结构上，有髓鞘内空泡，内周期线处板层分离，破裂空泡融合形成更大的间隙。免疫组织化学检测显示，脑干病变中未检测到朊病毒蛋白（PrP）异常积聚。据我们所知，这是首例局限于脑干核的猫海绵状变化的报告。
