Silva J C P, Santos J L, Barbosa A J A
Department of Veterinary Medicine, Federal University of Viçosa, School of Medicine, Brazil.
J Comp Pathol. 2002 Feb-Apr;126(2-3):235-7. doi: 10.1053/jcpa.2001.0541.
Gastric ulcer of the pars oesophagea (GUPO) of the stomach, which occurs spontaneously in swine, is of unknown aetiology. Because gastrin is a potent secretagogue linked to acid secretion, this study was designed to investigate, in pigs with or without GUPO, (1) basal and food-stimulated serum gastrin concentrations, (2) the concentration of tissue gastrin, and (3) gastrin-producing (G) cell density in the antral mucosa. Sixty-four pigs (32 with, and 32 without ulceration) were studied. Antral mucosa was obtained immediately after slaughter for assessment of G-cell number and tissue gastrin concentration. The presence or absence of GUPO was not significantly associated with either of the parameters measured.
猪胃食管部胃溃疡（GUPO）会自发出现，其病因不明。由于胃泌素是一种与胃酸分泌相关的强效促分泌素，本研究旨在调查有或没有GUPO的猪的（1）基础和食物刺激后的血清胃泌素浓度，（2）组织胃泌素浓度，以及（3）胃窦黏膜中胃泌素产生细胞（G细胞）密度。研究了64头猪（32头有溃疡，32头无溃疡）。屠宰后立即获取胃窦黏膜，以评估G细胞数量和组织胃泌素浓度。GUPO的有无与所测参数均无显著相关性。
