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慢性粒细胞白血病中的突发性听力损失与高黏滞综合征有关。

Sudden hearing loss in chronic myelogenous leukaemia implicating the hyperviscosity syndrome.

作者信息

Chae Sung Won, Cho Jae Hoon, Lee Jang Hyuck, Kang Hee Joon, Hwang Soon Jae

机构信息

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.

出版信息

J Laryngol Otol. 2002 Apr;116(4):291-3. doi: 10.1258/0022215021910564.

Abstract

Sudden sensorineural hearing loss that presents as the initial sign of haematological disease is very rare. Chronic myelogenous leukaemia has been implicated as a causative factor of sudden sensorineural hearing loss. A 49-year-old male presented with unilateral sudden sensorineural hearing loss. The patient was found to have chronic myelogenous leukaemia during a work-up for his hearing loss. We present a case of a chronic myelogenous leukaemia patient whose first manifestation was sudden sensorineural hearing loss. We presume that cochlear vessel occlusion as a result of elevated blood viscosity was responsible for this patient's hearing loss. Early onset of sudden deafness in a chronic myelogenous leukaemia patient may be due to the hyperviscosity syndrome and it may be possible to reverse hearing loss through early leukapheresis.

摘要

以突发性感音神经性听力损失作为血液系统疾病的首发症状极为罕见。慢性粒细胞白血病被认为是突发性感音神经性听力损失的一个致病因素。一名49岁男性出现单侧突发性感音神经性听力损失。该患者在针对其听力损失的检查过程中被发现患有慢性粒细胞白血病。我们报告一例以突发性感音神经性听力损失为首发表现的慢性粒细胞白血病患者。我们推测血液黏度升高导致的耳蜗血管阻塞是该患者听力损失的原因。慢性粒细胞白血病患者突发性耳聋的早期发作可能归因于高黏滞综合征,并且有可能通过早期白细胞去除术使听力损失得到逆转。

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