Bole G G, Jourdian G W, Wright J E
J Lab Clin Med. 1975 Dec;86(6):1018-31.
A saline soluble glycoprotein isolated from 14- and 42-day polyvinyl sponge granulomas was shown to depress in vitro phagocytosis by peritoneal macrophages. The glycoprotein had no effect on polymorphonuclear phagocytosis. Chemical and physical characterization of the inhibitor protein obtained from mature (42-day) granulomas developed in guinea pigs indicated that the protein had a molecular weight of 48,500 and an isoelectric point of 5.3. It was homogeneous when examined in three polyacrylamide disc gel electrophoretic buffer systems. The carbohydrate and amino acid content of the protein are reported. The chemical and physical characteristics of the inhibitor protein suggest that it is of nonserum origin. It is postulated that the glycoprotein inhibitor from chronic granulation tissue may participate in regulation of mononuclear phagocyte (macrophage) function within a local inflammatory focus.
从14天和42天的聚乙烯海绵肉芽肿中分离出的一种盐溶性糖蛋白，被证明可在体外抑制腹膜巨噬细胞的吞噬作用。该糖蛋白对多形核细胞的吞噬作用没有影响。对豚鼠体内成熟（42天）肉芽肿中获得的抑制蛋白进行化学和物理特性分析表明，该蛋白的分子量为48,500，等电点为5.3。在三种聚丙烯酰胺圆盘凝胶电泳缓冲系统中检测时，它是均一的。报告了该蛋白的碳水化合物和氨基酸含量。抑制蛋白的化学和物理特性表明它并非血清来源。据推测，慢性肉芽组织中的糖蛋白抑制剂可能参与局部炎症灶内单核吞噬细胞（巨噬细胞）功能的调节。
