Weimer E, Braus D F, Cavus I, Thome J
Zentralinstitut für Seelische Gesundheit Mannheim, Germany.
Fortschr Neurol Psychiatr. 2002 Apr;70(4):210-7. doi: 10.1055/s-2002-24644.
The treatment of severe depression represents a difficult task in the daily psychiatric practice. In certain cases, augmentation therapies in order to improve the efficacy of SSRIs can be useful. Recently, it has become possible to use atypical antipsychotics for SSRI augmentation. This option adds to the existing strategies in the treatment of depression and primary systematic studies show encouraging results. In this review, the possibility of a SSRI augmentation by additionally administering risperidone or olanzapine is critically discussed.
在日常精神病学实践中，重度抑郁症的治疗是一项艰巨的任务。在某些情况下，为提高选择性5-羟色胺再摄取抑制剂（SSRI）的疗效而采用增效疗法可能会有所帮助。近来，使用非典型抗精神病药物来增强SSRI的疗效已成为可能。这一选择为现有的抑郁症治疗策略增添了新方法，初步的系统性研究显示出了令人鼓舞的结果。在这篇综述中，我们将批判性地讨论通过额外给予利培酮或奥氮平来增强SSRI疗效的可能性。
