卡马西平晶型IV

Form IV of carbamazepine.

作者信息

Lang Meidong, Kampf Jeff W, Matzger Adam J

机构信息

Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055, USA.

出版信息

J Pharm Sci. 2002 Apr;91(4):1186-90. doi: 10.1002/jps.10093.

DOI:10.1002/jps.10093

PMID:11948557

Abstract

Carbamazepine has been found to crystallize as a new polymorph that is stable at room temperature. We report the crystal structure of this C-centered monoclinic form (space group C2/c, cell parameters: a = 26.609, b = 6.9269, c = 13.957, beta = 109.702), which consists of hydrogen bonded dimers with an anti-disposition. This represents the third modification of carbamazepine that has been crystallographically characterized, and the fourth for which cell parameters have been determined. Thus, it is designated as form IV of carbamazepine. Differences between the packing of the various polymorphs are discussed.

摘要

已发现卡马西平能结晶形成一种在室温下稳定的新多晶型物。我们报道了这种以C为中心的单斜晶型（空间群C2/c，晶胞参数：a = 26.609，b = 6.9269，c = 13.957，β = 109.702）的晶体结构，它由具有反式排列的氢键二聚体组成。这是已通过晶体学表征的卡马西平的第三种变体，也是已确定晶胞参数的第四种变体。因此，它被指定为卡马西平的IV型。讨论了各种多晶型物堆积之间的差异。