Wedding Kristin L, Draney Mary T, Herfkens Robert J, Zarins Christopher K, Taylor Charles A, Pelc Norbert J
Department of Radiology, Stanford University, Stanford, California 94304, USA.
J Magn Reson Imaging. 2002 Apr;15(4):418-28. doi: 10.1002/jmri.10077.
To determine the feasibility of using magnetic resonance imaging (MRI) to non-invasively measure strain in the aortic wall.
Cine phase contrast MRI was used to measure the velocity of the aortic wall and calculate changes in circumferential strain over the cardiac cycle. A deformable vessel phantom was used for initial testing and in vitro validation. Ultrasonic sonomicrometer crystals were attached to the vessel wall and used as a gold standard.
In the in vitro validation, MRI-calculated wall displacements were within 0.02 mm of the sonomicrometer measurements when maximal displacement was 0.28 mm. The measured maximum strain in vitro was 0.02. The in vivo results were on the same order as prior results using ultrasound echo-tracking.
Results of in vivo studies and measurement of cyclic strain in human thoracic and abdominal aortas demonstrate the feasibility of the technique.
确定使用磁共振成像（MRI）非侵入性测量主动脉壁应变的可行性。
电影相位对比MRI用于测量主动脉壁的速度，并计算心动周期中圆周应变的变化。使用可变形血管模型进行初始测试和体外验证。将超声测微计晶体附着在血管壁上，并用作金标准。
在体外验证中，当最大位移为0.28mm时，MRI计算的壁位移在超声测微计测量值的0.02mm范围内。体外测量的最大应变为0.02。体内结果与先前使用超声回声跟踪的结果处于同一量级。
人体胸主动脉和腹主动脉的体内研究结果及循环应变测量证明了该技术的可行性。
