Payne Donald N R, Balfour-Lynn Ian M, Biggart Elizabeth A, Bush Andrew, Rosenthal Mark
Department of Respiratory Medicine, Royal Brompton Hospital, London, UK.
Pediatr Pulmonol. 2002 May;33(5):356-61. doi: 10.1002/ppul.10081.
A continuous subcutaneous infusion of terbutaline (CSIT) was used to treat 8 children with chronic severe asthma who continued to experience frequent symptoms, despite treatment with regular oral prednisolone. Five patients experienced a symptomatic improvement from CSIT, leading to a reduction in regular medication. Three patients did not experience any lasting benefit from CSIT. The most common side effects were related to the infusion site (bruising and local infection). CSIT may lead to an improvement in symptoms and a reduction in oral steroid dose in selected children with chronic severe asthma. These initial findings support the need for further controlled studies to evaluate the use of CSIT in severe childhood asthma.
采用特布他林持续皮下输注（CSIT）治疗8例慢性重度哮喘患儿，这些患儿尽管规律口服泼尼松龙治疗，但仍频繁出现症状。5例患者通过CSIT症状改善，从而减少了常规用药。3例患者未从CSIT中获得任何持久益处。最常见的副作用与输注部位有关（瘀伤和局部感染）。CSIT可能会使部分慢性重度哮喘患儿的症状得到改善，并减少口服类固醇剂量。这些初步研究结果支持有必要开展进一步的对照研究，以评估CSIT在儿童重度哮喘中的应用。
