Horwitz N H, Curtin J A
J Neurosurg. 1975 Dec;43(6):727-31. doi: 10.3171/jns.1975.43.6.0727.
The authors review 531 consecutive operations for lumbar disc herniation performed on 496 patients by one neurosurgeon to determine the effect of prophylactic antibiotics upon postoperative wound infections. In this retrospective analysis 16 instances of sepsis were found, 11 considered to be major and five minor. In the 128 cases in which no antibacterial agents were given, 11 major and 1 minor infection occurred. Four minor infections developed in the 402 occasions when antibiotics were given in the perioperative period. Men had a significantly greater risk of developing infection than women. These data suggest that pre- and postoperative antibiotic therapy directed at a narrow spectrum of microorganisms reduced the incidence of significant wound infections in patients undergoing laminectomy for lumbar disc herniation.
作者回顾了一位神经外科医生为496例患者连续实施的531例腰椎间盘突出症手术，以确定预防性使用抗生素对术后伤口感染的影响。在这项回顾性分析中，发现了16例脓毒症病例，其中11例被认为是严重的，5例为轻微的。在未使用抗菌药物的128例病例中，发生了11例严重感染和1例轻微感染。在围手术期使用抗生素的402例中，出现了4例轻微感染。男性发生感染的风险显著高于女性。这些数据表明，针对窄谱微生物的术前和术后抗生素治疗降低了接受腰椎间盘突出症椎板切除术患者严重伤口感染的发生率。
