人绒毛膜促性腺激素减弱血管对血管紧张素II的反应。

Human chorionic gonadotropin attenuates the vascular response to angiotensin II.

作者信息

Hermsteiner Markus, Zoltan Dorina R, Künzel Wolfgang

机构信息

Department of Obstetrics and Gynecology, Justus Liebig University, Klinikstrasse 32, D-35392 Giessen, Germany.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2002 May 10;102(2):148-54. doi: 10.1016/s0301-2115(01)00607-8.

DOI:10.1016/s0301-2115(01)00607-8

PMID:11950482

Abstract

OBJECTIVE

Our purpose was to investigate interactions between human chorionic gonadotropin (hCG) and angiotensin II (ANG II) in resistance arteries.

STUDY DESIGN

Isolated pre-arteriolar vessels of female Sprague-Dawley rats were prepared from the mesenteric arcade and the mesometrium. Dose-response curves were recorded by means of an video-electronic arteriograph system.

RESULTS

(1) hCG dilated mesenteric (MA; EC(50): 21+/-6.9 mU/ml) and uterine (UA; EC(50): 256+/-44.3 mU/ml)) resistance arteries pre-constricted with ANG II. In the presence of glybenclamide (1 micromol/l), the response of MA was reduced by >50%. (2) After application of hCG for 1h, vasoconstriction by ANG II was significantly attenuated in MA. This effect was dose-dependent and was not observed in UA. Efficacy of ANG II could be restored, when hCG was followed by glybenclamide.

CONCLUSIONS

hCG may contribute to the reduction in arterial tone seen early in human pregnancy. Its vascular effects are in part mediated by the activation of adenosine 5'-triphosphate-sensitive potassium channels, suggesting a protein kinase A dependent signaling pathway.

摘要

目的

我们的目的是研究人绒毛膜促性腺激素（hCG）与血管紧张素II（ANG II）在阻力动脉中的相互作用。

研究设计

从雌性Sprague-Dawley大鼠的肠系膜弓和子宫系膜制备分离的小动脉前血管。通过视频电子动脉造影系统记录剂量反应曲线。

结果

（1）hCG使预先用ANG II收缩的肠系膜（MA；半数有效浓度（EC50）：21±6.9 mU/ml）和子宫（UA；EC50：256±44.3 mU/ml）阻力动脉扩张。在存在格列本脲（1 μmol/l）的情况下，MA的反应降低>50%。（2）应用hCG 1小时后，ANG II引起的MA血管收缩明显减弱。这种作用是剂量依赖性的，在UA中未观察到。当hCG后接着使用格列本脲时，ANG II的效力可以恢复。