van Schie Debby L, de Jeu Renate M, Steyn D Wilhelm, Odendaal Hein J, van Geijn Herman P
Department of Obstetrics and Gynaecology, VU Medical Center, Amsterdam, The Netherlands.
Eur J Obstet Gynecol Reprod Biol. 2002 May 10;102(2):161-6. doi: 10.1016/s0301-2115(01)00611-x.
To establish the optimal dosage of ketanserin in the treatment of severe hypertension in pregnancy.
A double blind prospective randomised controlled trail, comparing 10 mg ketanserin given as intravenous boluses either every 10 or 20 min, until the therapeutic goal of 90 mmHg (diastolic blood pressure) was reached, to a maximum of eight boluses. Main outcome measures were treatment failures and caesarean sections for fetal distress.
There was no difference in reaching the therapeutic goal between patients receiving 10 mg ketanserin either every 10 or 20 min.
Ketanserin appears to be an attractive medicine in the treatment of severe hypertension in pregnancy, but the optimal dosage could not be established.
确定酮色林治疗妊娠重度高血压的最佳剂量。
一项双盲前瞻性随机对照试验，将每10分钟或20分钟静脉推注10毫克酮色林直至达到舒张压90毫米汞柱的治疗目标（最多推注8次）与对照组进行比较。主要观察指标为治疗失败情况及因胎儿窘迫行剖宫产的情况。
每10分钟或20分钟接受10毫克酮色林治疗的患者在达到治疗目标方面无差异。
酮色林似乎是治疗妊娠重度高血压的一种有吸引力的药物，但无法确定最佳剂量。
