Mahjoub Moe R, Montpetit Ben, Zhao Lifan, Finst Rip J, Goh Benjamin, Kim Apollos C, Quarmby Lynne M
Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada V5A 1S6.
J Cell Sci. 2002 Apr 15;115(Pt 8):1759-68. doi: 10.1242/jcs.115.8.1759.
The NIMA kinases are one of several families of kinases that participate in driving the eukaryotic cell cycle. NIMA-related kinases have been implicated in G2/M progression, chromatin condensation and regulation of the centrosome cycle. Here we report the identification of a new member of this family, FA2, from Chlamydomonas reinhardtii. FA2 was originally discovered in a genetic screen for deflagellation-defective mutants. We have previously shown that FA2 is essential for basal-body/centriole-associated microtubule severing. We now report that the FA2 NIMA-related kinase also plays a role in cell cycle progression in Chlamydomonas. This is the first indication that members of the NIMA family might exert their effects through the regulation of microtubule severing.
NIMA激酶是参与驱动真核细胞周期的几个激酶家族之一。NIMA相关激酶与G2/M期进程、染色质凝聚以及中心体周期调控有关。在此，我们报告从莱茵衣藻中鉴定出该家族的一个新成员FA2。FA2最初是在一项针对脱鞭毛缺陷突变体的遗传筛选中发现的。我们之前已经表明，FA2对于基体/中心粒相关微管切断至关重要。我们现在报告，FA2 NIMA相关激酶在衣藻的细胞周期进程中也发挥作用。这首次表明NIMA家族成员可能通过调控微管切断发挥作用。
