Crumrine Patricia K
Division of Child Neurology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, PA 15213-2583, USA.
J Child Neurol. 2002 Feb;17 Suppl 2:2S2-2S8. doi: 10.1177/08830738020170020701.
This review article presents information concerning treatment options for various pediatric epilepsy syndromes. The decisions made in the selection of antiepileptic drugs are deternined by a number of variables that include, but are exclusive of, risk of seizure recurrence, patient age, epilepsy syndrome, known drug reactions, and prognosis of the epilepsy syndrome. The review discusses issues pertinent to antiepileptic drug selection including simple pharmacokinetic principles, antiepileptic drug formulations, and information concerning clinical studies using some of the antiepileptic drugs. Information is provided concerning the issues of seizure recurrence. Suggested paradigms for antiepileptic drug selection for partial seizures are provided. A table of antiepileptic drug costs is provided for assistance in prescribing and advising families. Psychosocial issues pertinent to the treatment of children are discussed.
这篇综述文章介绍了各种小儿癫痫综合征的治疗选择相关信息。选择抗癫痫药物时所做的决定由多个变量决定，这些变量包括但不限于癫痫复发风险、患者年龄、癫痫综合征、已知药物反应以及癫痫综合征的预后。该综述讨论了与抗癫痫药物选择相关的问题，包括简单的药代动力学原理、抗癫痫药物剂型，以及一些抗癫痫药物的临床研究信息。还提供了癫痫复发问题的相关信息。给出了部分性发作抗癫痫药物选择的建议模式。提供了抗癫痫药物费用表，以协助开处方和为家庭提供建议。讨论了与儿童治疗相关的社会心理问题。
