Smith Terry J
Division of Molecular Medicine, Harbor-UCLA Medical Center, Torrance, California 90502-2006, USA.
Thyroid. 2002 Mar;12(3):197-203. doi: 10.1089/105072502753600133.
Thyroid-associated ophthalmopathy (TAO) represents a process confined to the orbit where the connective tissue becomes inflamed and accumulates the glycosaminoglycan, hyaluronan. Ultimately, the orbital tissues become extensively remodeled. Evidence points to the recruitment and activation of T cells as critical elements initiating and driving the pathogenesis of TAO. The phenotype of orbital fibroblasts appears to be distinct from that of other types of fibroblasts. These cells exhibit particularly robust responses to a number of T-cell-derived cytokines. Notable among these are the inductions of key inflammatory genes and their products. We hypothesize that exaggerated cellular responses represent the basis for the involvement of the orbit in Graves' disease.
甲状腺相关眼病（TAO）是一种局限于眼眶的病变，其中结缔组织发生炎症并积聚糖胺聚糖——透明质酸。最终，眼眶组织会发生广泛重塑。有证据表明，T细胞的募集和激活是引发和推动TAO发病机制的关键因素。眼眶成纤维细胞的表型似乎与其他类型的成纤维细胞不同。这些细胞对多种T细胞衍生的细胞因子表现出特别强烈的反应。其中值得注意的是关键炎症基因及其产物的诱导。我们推测，过度的细胞反应是眼眶参与格雷夫斯病的基础。
