Bondarenko Vladimir A, Yu Hao, Yamazaki Russell K, Yamazaki Akio
Kresge Eye Institute and Department of Ophthalmology, Wayne State University, School of Medicine, Detroit, MI 48201, USA.
Mol Cell Biochem. 2002 Jan;230(1-2):125-8.
Cyclic GMP plays a key role in retinal phototransduction and its photoreceptor concentration is precisely controlled by the cooperative action of cGMP phosphodiesterase (PDE) and retinal guanylyl cyclase (retGC). However, studies of the relationship between these two systems have focused only on a Ca2+-mediated, indirect connection. This article summarizes our studies strongly suggesting that RGS9-1 is directly involved in the cooperative action of PDE and retGC, and that this ingenious mechanism plays an important role in tuning of cGMP concentration in photoreceptors.
环磷酸鸟苷（cGMP）在视网膜光转导中起关键作用，其在光感受器中的浓度由cGMP磷酸二酯酶（PDE）和视网膜鸟苷酸环化酶（retGC）的协同作用精确控制。然而，对这两个系统之间关系的研究仅集中在Ca2+介导的间接联系上。本文总结了我们的研究，强烈表明RGS9-1直接参与PDE和retGC的协同作用，并且这种巧妙的机制在调节光感受器中cGMP浓度方面发挥重要作用。
