Maw R D, Kinghorn G R, Bowman C A, Goh B T, Nayagam A T, Nathan M
Department of Genitourinary Medicine, Royal Victoria Hospital, Belfast, Northern Ireland, UK.
J Eur Acad Dermatol Venereol. 2002 Jan;16(1):58-62. doi: 10.1046/j.1468-3083.2002.00366.x.
To determine the safety and efficacy of imiquimod (Aldara) 5% cream in the treatment of prepuce-associated warts in uncircumcised males.
An open-label study in six UK medical centres with 35 uncircumcised males with prepuce-associated warts treated with imiquimod 5% cream three times per week for up to 16 weeks. Other anogenital warts were also treated.
Three times weekly application of imiquimod was found to be safe, with erythema as the most commonly reported local skin reaction. Forty per cent of patients had complete clearance of anogenital warts within 16 weeks.
Imiquimod cream at a dosing regimen of three times per week, is effective and has an acceptable safety profile in the treatment of prepuce associated warts and other external anogenital warts in uncircumcised males.
确定5%咪喹莫特乳膏（艾达乐）治疗未行包皮环切术男性的包皮相关疣的安全性和有效性。
在英国六个医学中心开展的一项开放性研究，纳入35例患有包皮相关疣的未行包皮环切术男性，每周三次外用5%咪喹莫特乳膏，持续16周。其他肛门生殖器疣也一并接受治疗。
发现每周三次外用咪喹莫特是安全的，最常见的局部皮肤反应是红斑。40%的患者在16周内肛门生殖器疣完全清除。
每周三次给药方案的咪喹莫特乳膏，在治疗未行包皮环切术男性的包皮相关疣和其他肛门生殖器外疣方面有效且安全性可接受。
