干燥综合征和口干患者小唾液腺活检结果呈阳性的危险因素。

Risk factors for positive minor salivary gland biopsy findings in Sjögren's syndrome and dry mouth patients.

作者信息

Brennan Michael T, Sankar Vidya, Leakan Rose Anne, Kleiner David, Atkinson Jane C, Wilkinson William E, Baum Bruce J, Pillemer Stanley R

机构信息

National Institute of Dental and Craniofacial Research (NIDCR), NIH, Bethesda, Maryland, USA.

出版信息

Arthritis Rheum. 2002 Apr 15;47(2):189-95. doi: 10.1002/art.10219.

DOI:10.1002/art.10219

PMID:11954013

Abstract

OBJECTIVE

To investigate risk factors for positive minor salivary gland biopsy results in Sjögren's syndrome (SS) and dry mouth patients.

METHODS

A total of 289 patients with dry mouth symptoms were evaluated. Potential risk factors for positive minor salivary gland biopsy results (>1 focus of lymphocytes) were studied in 2 phases. In phase 1, predictor variable candidates were identified for the test study (phase 2). Odds ratios were calculated for predictor variables.

RESULTS

IgG, IgA, keratoconjunctivitis sicca, and sex, identified as the best predictor variables from phase 1 data, were included in a logistic regression model using phase 2 data. Only IgG demonstrated association with biopsy results (chi(2) = 20.4, P = 0.0001). An elevated IgG level (>1,482 mg/dl) had a high specificity (97% and 97%), high positive predictive value (PPV) (97% and 97%), but poor sensitivity (40% and 45%) in predicting positive biopsy results and SS, respectively.

CONCLUSION

Elevated serum IgG levels best predicted a positive biopsy result and SS with high PPV and specificities.

摘要

目的

研究干燥综合征（SS）和口干患者小唾液腺活检结果为阳性的危险因素。

方法

对总共289例有口干症状的患者进行评估。小唾液腺活检结果为阳性（淋巴细胞灶>1个）的潜在危险因素分两个阶段进行研究。在第一阶段，确定用于测试研究（第二阶段）的预测变量候选因素。计算预测变量的比值比。

结果

IgG、IgA、干燥性角结膜炎和性别，从第一阶段数据中确定为最佳预测变量，被纳入使用第二阶段数据的逻辑回归模型。只有IgG显示出与活检结果相关（χ² = 20.4，P = 0.0001）。IgG水平升高（>1482mg/dl）在预测活检结果为阳性和SS时分别具有高特异性（97%和97%）、高阳性预测值（PPV）（97%和97%），但敏感性较差（40%和45%）。