Liu Zuguo, Zhang Mei, Chen Jiaqi, Ye Tiancai, Chen Longshan, Huang Ting, Lin Yuesheng, Feng Chunmao
Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China (Email:
Zhonghua Yan Ke Za Zhi. 2002 Jan;38(1):16-20.
To study the clinical characteristics of the contralateral eyes in patients with unilateral iridocorneal endothelial syndrome (ICE).
The clinical characteristics were analyzed retrospectively on the contralateral eyes in 42 cases of unilateral ICE. Among them, 19 patients (19 eyes) received examinations of refraction, intraocular pressure (IOP), slit lamp, gonioscopy and ultrasound biomicroscopy. In the 35 cases (35 eyes), the endothelial cell counts of the contralateral eyes were compared with age-matched normal controls using t-test.
In the 19 cases of unilateral ICE syndrome, emmetropia or hypermetropia were found in 88.9%, IOP higher than 21 mm Hg was present in one case, and anterior chamber depth lower than 2.2 mm was in 50.0%. Atrophy or dysplasia of iris existed in 3 cases, there were narrowness and/or adhesion of anterior chamber angle in 3 cases and pyramidal adhesion under gonioscopy and/or ultrasound biomicroscopy examination in 2 cases. One case represented relative paracentral scotoma in the visual field examination. Systematic disorders, including hepatitis B, diabetes, hyperthyroidism, duodenum ulceration, hypertension were found in 31.6%. In the 35 patients who received endothelial cell count, the average endothelial cell density of the contralateral eyes was (2 593.4 +/- 432.7)/mm(2), which was significantly lower than that of the normal controls (2 784.9 +/- 280.6)/mm(2) (t = -2.43, P = 0.019). The hexagonality and coefficient variation of cell size of ICE patients did not differ from that of the normal controls.
The contralateral eye in cases diagnosed as unilateral ICE syndrome may be subclinically involved, so it is necessary to pay attention to the contralateral eye, and follow up all the patients suffered from ICE syndrome.
研究单眼虹膜角膜内皮综合征（ICE）患者对侧眼的临床特征。
回顾性分析42例单眼ICE患者对侧眼的临床特征。其中19例患者（19只眼）接受了验光、眼压（IOP）、裂隙灯、前房角镜及超声生物显微镜检查。对35例患者（35只眼），采用t检验将对侧眼的内皮细胞计数与年龄匹配的正常对照进行比较。
在19例单眼ICE综合征患者中，88.9%为正视或远视，1例眼压高于21 mmHg，50.0%前房深度低于2.2 mm。3例存在虹膜萎缩或发育异常，3例有前房角狭窄和/或粘连，2例在前房角镜和/或超声生物显微镜检查下可见锥形粘连。1例在视野检查中表现为相对旁中心暗点。31.6%发现有系统性疾病，包括乙型肝炎、糖尿病、甲状腺功能亢进、十二指肠溃疡、高血压。在接受内皮细胞计数的35例患者中，对侧眼的平均内皮细胞密度为（2 593.4±432.7）/mm²，显著低于正常对照（2 784.9±280.6）/mm²（t = -2.43，P = 0.019）。ICE患者细胞大小的六角形度和变异系数与正常对照无差异。
诊断为单眼ICE综合征患者的对侧眼可能存在亚临床受累，因此有必要关注对侧眼，并对所有ICE综合征患者进行随访。
