[成釉细胞瘤中外周细胞与中心细胞的增殖活性及分化]

[Proliferating activity and differentiation between peripheral cells and central cells in ameloblastoma].

作者信息

Liu Jinzhong, Wang Shuozhi, Chen Xinming, Li Yuan

机构信息

Department of Oral Pathology, College of Stomatology, Wuhan University, Wuhan 430079, China.

出版信息

Zhonghua Kou Qiang Yi Xue Za Zhi. 2002 Jan;37(1):62-4.

PMID:11955366

Abstract

OBJECTIVE

To investigate the proliferating activities and differentiation between peripheral cells and central cells in ameloblastoma.

METHODS

Expressions of proliferating cell nuclear antigen (PCNA), Ki-67, CK10&13 and CK19 were detected in 43 ameloblastoma (15 follicular, 20 plexiform and 8 acanthomatous) by SP immunohistochemical methods.

RESULTS

The PCNA labelling indices were significantly higher in peripheral cells (5.12% +/- 2.76%) of tumour nests or strands than in central cells (1.36% +/- 1.02%, P < 0.001). The peripheral cells of tumour nests or strands exhibited a significantly higher Ki-67 labelling index (3.63% +/- 1.80%) than central cells (1.26% +/- 0.96%, P < 0.001). The labelling indices between PCNA and Ki-67 showed a significant correlation (P < 0.01). The positive expressions of CK10&13 and CK19 were significantly higher in central cells than in peripheral cells (P < 0.01).

CONCLUSIONS

The peripheral zones of tumour nests or strands are regarded as proliferating areas; there exists a significantly different differentiation between central cells and peripheral cells.

摘要

目的

研究成釉细胞瘤外周细胞与中心细胞的增殖活性及分化情况。

方法

采用SP免疫组织化学方法检测43例成釉细胞瘤（滤泡型15例、丛状型20例、棘皮瘤型8例）中增殖细胞核抗原（PCNA）、Ki-67、细胞角蛋白10和13（CK10&13）以及细胞角蛋白19（CK19）的表达。

结果

肿瘤巢或条索外周细胞的PCNA标记指数（5.12%±2.76%）显著高于中心细胞（1.36%±1.02%，P<0.001）。肿瘤巢或条索外周细胞的Ki-67标记指数（3.63%±1.80%）显著高于中心细胞（1.26%±0.96%，P<0.001）。PCNA与Ki-67的标记指数之间存在显著相关性（P<0.01）。CK10&13和CK19的阳性表达在中心细胞中显著高于外周细胞（P<0.01）。