[原发性乳腺癌中血管生成及nm23-H(1)肿瘤转移抑制基因的表达及其与淋巴结转移的关系]
[Angiogenesis and the expression of nm23-H(1) tumor metastatic suppressor gene in primary breast carcinoma and their relations to lymph node metastasis].
作者信息
Li Yingjia, Wu Fenglin, Gong Weibing
机构信息
Departement of Ultrasonography, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
出版信息
Zhonghua Wai Ke Za Zhi. 2002 Mar;40(3):177-9.
OBJECTIVE
To study angiogenesis and the expression of nm23-H(1) tumor metastatic suppressor gene in primary breast carcinoma and their relationship with axillary lymph node metastasis.
METHODS
Intratumoral vascularization in 80 cases of breast cancer was observed preoperatively by power doppler imaging (PDI) and analysed with computer-assisted quantative assessment, and the expression of microvessel density (MVD) and nm23 protein was determined by immunohistochemical technique.
RESULTS
Blood flow signals and blood vessels postitive area within masses were more in axillary node positive (LN+) group than in axillary node negative (LN-) group (t = 7.07, P < 0.01), MVD expression were higher in the LN+ group than in the LN- group (t = 6.34, P < 0.01). Meanwhile the expression of nm23-H(1) protein was lower in the LN+ group than in the LN- group, and significant correlation was found between angiogenesis and the expression of nm23-H(1) protein.
CONCLUSIONS
Angiogenesis and the expression of nm23-H(1) protein may play an important role in the lymphatic metastasis process of breast cancer. Furthermore, angiogenesis may correlates with the expression of nm23-H(1) protein in that progress.
目的
研究原发性乳腺癌中血管生成及nm23-H(1)肿瘤转移抑制基因的表达情况及其与腋窝淋巴结转移的关系。
方法
术前采用能量多普勒成像（PDI）观察80例乳腺癌患者瘤内血管形成情况，并通过计算机辅助定量评估进行分析，采用免疫组织化学技术检测微血管密度（MVD）及nm23蛋白的表达。
结果
腋窝淋巴结阳性（LN+）组肿块内血流信号及血管阳性面积多于腋窝淋巴结阴性（LN-）组（t = 7.07，P < 0.01），LN+组MVD表达高于LN-组（t = 6.34，P < 0.01）。同时，LN+组nm23-H(1)蛋白表达低于LN-组，且血管生成与nm23-H(1)蛋白表达之间存在显著相关性。
结论
血管生成及nm23-H(1)蛋白表达可能在乳腺癌淋巴转移过程中起重要作用。此外，在该过程中血管生成可能与nm23-H(1)蛋白表达相关。
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