Chung M-K, Kim J-C, Han S-S
Reproductive Toxicology Division, Toxicology Research Center, Korea Research Institute of Chemical Technology, Yuseong, Daejeon 305-600, Republic of Korea.
Food Chem Toxicol. 2002 May;40(5):723-9. doi: 10.1016/s0278-6915(01)00127-2.
Flupyrazofos is a new type of pyrazole organophosporus insecticide, which has a high activity against the diamond-back moth (Plutella xylostella). The potential of this agent to induce developmental toxicity was investigated in the Sprague-Dawley rat. One hundred mated females (sperm in vaginal LAVAGE=day 0) were distributed among three treated groups and a control group. Flupyrazofos was administered by gavage to pregnant rats from days 7-17 of gestation at dose levels of 0, 5, 12 and 30 mg/kg/day. All dams were subjected to the caesarean section on day 20 of gestation and their fetuses were examined for external, visceral and skeletal abnormalities. At 30 mg/kg, maternal effects including mortality (4.3%), clinical signs of toxicity, decreased food intake, suppressed body weight, and increased weight of adrenal glands, kidney and heart were observed in dams. Litter values for corpora lutea, implantations, sex ratio and litter size were within the normal range. However, a reduction in the fetal weight and an increase in the incidence of fetal skeletal retardations were observed. At 12 mg/kg, toxic effects including mortality (4.2%), nasal discharge and some fetal skeletal retardation were observed. There were no signs of either maternal toxicity or embryotoxicity at 5 mg/kg. The results show that flupyrazofos induces fetal growth retardation only at maternally toxic doses in rats and the no-observed-adverse-effect levels (NOAELs) of this agent are considered to be 5 mg/kg for both dams and fetuses.
氟吡唑磷是一种新型吡唑类有机磷杀虫剂，对小菜蛾具有高活性。在斯普拉格-道利大鼠中研究了该药剂诱发发育毒性的可能性。100只已交配的雌性大鼠（阴道灌洗中有精子=第0天）被分配到三个处理组和一个对照组。在妊娠第7至17天，对怀孕大鼠经口灌胃给予氟吡唑磷，剂量水平分别为0、5、12和30毫克/千克/天。所有母鼠在妊娠第20天接受剖腹产，并检查其胎儿的外部、内脏和骨骼异常情况。在30毫克/千克剂量时，在母鼠中观察到母体效应，包括死亡率（4.3%）、毒性临床体征、食物摄入量减少、体重抑制以及肾上腺、肾脏和心脏重量增加。黄体数、着床数、性别比和窝仔数均在正常范围内。然而，观察到胎儿体重减轻和胎儿骨骼发育迟缓发生率增加。在12毫克/千克剂量时，观察到毒性效应，包括死亡率（4.2%）、鼻分泌物和一些胎儿骨骼发育迟缓。在5毫克/千克剂量时，未观察到母体毒性或胚胎毒性迹象。结果表明，氟吡唑磷仅在对母鼠产生毒性的剂量下才会诱发大鼠胎儿生长迟缓，该药剂对母鼠和胎儿的未观察到有害作用水平（NOAELs）均被认为是5毫克/千克。
