甘丙肽样肽刺激大鼠进食。
Galanin-like peptide stimulates food intake in the rat.
作者信息
Matsumoto Yoshio, Watanabe Takuya, Adachi Yuka, Itoh Takashi, Ohtaki Tetsuya, Onda Haruo, Kurokawa Tsutomu, Nishimura Osamu, Fujino Masahiko
机构信息
Pharmaceutical Research Division, Takeda Chemical Industries Ltd., Jusohonmachi 2-17-85, Yodogawa, Osaka, 532-8686, Japan.
出版信息
Neurosci Lett. 2002 Mar 29;322(1):67-9. doi: 10.1016/s0304-3940(01)02515-0.
We have isolated a novel hypothalamic peptide, Galanin-like peptide (GALP), as a ligand for galanin receptor subtype GalR2. To investigate the physiological role of GALP, we examined the effect of the intracerebroventricular administration of GALP and found that GALP induced food intakes. GALP had ten-fold the orexigenic activity of galanin. We also observed the anxiogenic-like behavior after the administration of 1 nmol GALP. These results suggest that GALP is a novel orexigenic and anxiogenic peptide.
我们已经分离出一种新型下丘脑肽，即甘丙肽样肽（GALP），作为甘丙肽受体亚型GalR2的配体。为了研究GALP的生理作用，我们检测了脑室内注射GALP的效果，发现GALP可诱导食物摄入。GALP的促食欲活性是甘丙肽的10倍。我们还观察到注射1 nmol GALP后出现类似焦虑的行为。这些结果表明，GALP是一种新型的促食欲和致焦虑肽。
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