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2-Chloro-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y1 receptor antagonist: commentary on Boyer et al.

作者信息

King Brian F

机构信息

Department of Physiology and Autonomic Neuroscience Institute, University College London, Royal Free Campus, Rowland Hill Street, Hampstead, London NW3 2PF, UK.

出版信息

Br J Pharmacol. 2002 Apr;135(8):1839-40. doi: 10.1038/sj.bjp.0704674.

DOI:10.1038/sj.bjp.0704674
PMID:11959784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1573331/
Abstract
摘要

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2-Chloro-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y1 receptor antagonist: commentary on Boyer et al.2-氯-N6-甲基-（N）-甲碳环-2'-脱氧腺苷-3'，5'-二磷酸是一种选择性高亲和力P2Y1受体拮抗剂：对博耶等人文章的评论
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本文引用的文献

1
Activity of Novel Adenine Nucleotide Derivatives as Agonists and Antagonists at Recombinant Rat P2X Receptors.新型腺嘌呤核苷酸衍生物作为重组大鼠P2X受体激动剂和拮抗剂的活性
Drug Dev Res. 2000 Apr 1;49(4):253-259. doi: 10.1002/1098-2299(200004)49:4<253::AID-DDR4>3.0.CO;2-1. Epub 2000 Jun 12.
2
2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist.2-氯-N(6)-甲基-(N)-甲碳环-2'-脱氧腺苷-3',5'-二磷酸是一种选择性高亲和力P2Y(1)受体拮抗剂。
Br J Pharmacol. 2002 Apr;135(8):2004-10. doi: 10.1038/sj.bjp.0704673.
3
Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.尿嘧啶和腺嘌呤核苷酸的甲碳硼烷修饰：在P2Y1、P2Y2、P2Y4和P2Y11受体上北环构象具有高效能，但在P2Y6受体上则不然。
J Med Chem. 2002 Jan 3;45(1):208-18. doi: 10.1021/jm010369e.
4
Identification of a novel human ADP receptor coupled to G(i).一种与G(i)偶联的新型人类ADP受体的鉴定。
J Biol Chem. 2001 Nov 2;276(44):41479-85. doi: 10.1074/jbc.M105912200. Epub 2001 Aug 23.
5
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands.核糖修饰的脱氧腺苷二磷酸类似物作为P2Y(1)受体配体的合成、生物活性及分子模拟
J Med Chem. 2000 Mar 9;43(5):829-42. doi: 10.1021/jm990249v.
6
On the suitability of adenosine 3'-phosphate 5'-phosphosulphate as a selective P2Y receptor antagonist in intact tissues.关于3'-磷酸-5'-磷酸硫酸腺苷作为完整组织中选择性P2Y受体拮抗剂的适用性
Eur J Pharmacol. 1998 Jun 19;351(2):209-15. doi: 10.1016/s0014-2999(98)00309-4.
7
Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate.N6-甲基2'-脱氧腺苷3',5'-二磷酸对P2Y1受体的竞争性和选择性拮抗作用。
Br J Pharmacol. 1998 May;124(1):1-3. doi: 10.1038/sj.bjp.0701837.
8
Identification of competitive antagonists of the P2Y1 receptor.P2Y1受体竞争性拮抗剂的鉴定。
Mol Pharmacol. 1996 Nov;50(5):1323-9.
9
Cloning and functional expression of a brain G-protein-coupled ATP receptor.一种脑G蛋白偶联ATP受体的克隆与功能表达。
FEBS Lett. 1993 Jun 14;324(2):219-25. doi: 10.1016/0014-5793(93)81397-i.