Taskin Omur, Onoglu Ahmet, Inal Murat, Turan Ersadik, Sadik Salih, Vardar Enver, Postaci Hakan, Wheeler James M
Department of Obstetrics and Gynecology, Akdeniz University Medical School, Antalya, Turkey.
J Am Assoc Gynecol Laparosc. 2002 May;9(2):186-90. doi: 10.1016/s1074-3804(05)60130-2.
To outline long-term histologic features of endometrial ablation.
Prospective longitudinal study (Canadian Task Force classification II-3).
Tertiary-care teaching hospital.
Twenty-six patients.
Thermal ablation followed by second-look office hysteroscopy with endometrial biopsy.
Mean follow-up time to second-look hysteroscopy after ablation was 33.4 +/- 2,1 months. Complete atrophy, partial adhesions or obliteration of the cavity, and fibrosis were observed at second-look hysteroscopy. Whereas all random biopsies were normal before ablation, biopsies after ablation revealed diminished endometrial glands with necrosis and scarring. The number of endometrial glands was not correlated with amount of bleeding or menstrual pattern. No premalignant or malignant lesions were found after ablation.
Although efficacy of endometrial ablation is related to initial thermal destruction and correlated with postablation hysteroscopic and histologic findings, endometrial regrowth is an expected development, not a failure of ablation.
概述子宫内膜消融的长期组织学特征。
前瞻性纵向研究（加拿大工作组分类II-3）。
三级护理教学医院。
26例患者。
热消融，随后在门诊进行二次宫腔镜检查并取子宫内膜活检。
消融后至二次宫腔镜检查的平均随访时间为33.4±2.1个月。二次宫腔镜检查时观察到完全萎缩、部分粘连或宫腔闭塞以及纤维化。消融前所有随机活检均正常，而消融后的活检显示子宫内膜腺体减少伴坏死和瘢痕形成。子宫内膜腺体数量与出血量或月经模式无关。消融后未发现癌前或恶性病变。
虽然子宫内膜消融的疗效与初始热损伤有关，并与消融后宫腔镜检查及组织学结果相关，但子宫内膜再生是预期的发展情况，而非消融失败。
