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发展中国家癫痫手术理想候选人的选择

Selection of ideal candidates for epilepsy surgery in developing countries.

作者信息

Cherian P J, Radhakrishnan K

机构信息

R. Madhavan Nayar Centre for Comprehensive Epilepsy Care, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, Kerala, 695 011, India.

出版信息

Neurol India. 2002 Mar;50(1):11-6.

Abstract

In order to become cost-effective, epilepsy surgery centers in developing countries will have to achieve excellent results by selecting candidates destined to have a seizure-free outcome using locally available limited technology and expertise, without compromising on patient safety. Our experience illustrates that this goal can be accomplished by selecting patients, whose epileptogenic zone can be unquestionably established, based on history, magnetic resonance imaging, and interictal and ictal scalp electroencephalogram findings. Patients with mesial temporal lobe epilepsy, and those with circumscribed potentially epileptogenic lesions belong to this category. A stepwise approach by reserving more difficult to treat patients to later date as experience develops, or by referring them to a better-equipped center, will help each center to understand its capabilities and limitations and to move forward. It would be essential to work with and educate the local public and professionals, if the epilepsy surgery program in a developing region were to have a lasting impact, It is encouraging to note that, despite major challenges, in the last one-decade, several epilepsy centers in the developing world have not only successfully implemented epilepsy surgery programs, but also have produced results comparable to that from developed countries at a fractional cost.

摘要

为了实现成本效益,发展中国家的癫痫手术中心将不得不利用当地有限的技术和专业知识,通过挑选注定能无癫痫发作的患者来取得优异成果,同时不损害患者安全。我们的经验表明,通过根据病史、磁共振成像以及发作间期和发作期头皮脑电图结果挑选出能明确确定致痫区的患者,这一目标是可以实现的。内侧颞叶癫痫患者以及有局限性潜在致痫性病变的患者属于这一类别。随着经验的积累,采取逐步推进的方法,将更难治疗的患者留到以后,或者将他们转诊到设备更好的中心,这将有助于每个中心了解自身的能力和局限性并不断前进。如果发展中地区的癫痫手术项目要有持久影响,与当地公众和专业人员合作并对他们进行教育至关重要。令人鼓舞的是,尽管面临重大挑战,但在过去十年中,发展中世界的几个癫痫中心不仅成功实施了癫痫手术项目,而且还以极低的成本取得了与发达国家相当的成果。

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