Suri A, Mehta V S, Sarkar C
Department of Neurosurgery, All India Institute of Medical Sciences, Neurosciences Center, New Delhi, 110029, India.
Neurol India. 2002 Mar;50(1):23-6.
An experimental study was designed to compare the histological analysis of nerve anastomosis with 10-0 microsurgical sutures and fibrin adhesive. Wistar albino rats' sciatic nerves were transected and repaired either with fibrin adhesive-Beriplast P (M/s Centeon-Cadila Health Care) or with 10-0 monofilament microsutures. Histological assessment was performed at 10, 20, 30, 60 and 90 days after surgery. Functional recovery of the sciatic nerves started at two months and was near normal by three months. Separation of the stumps did not occur in any of the glued nerves. Histological evaluation showed no appreciable difference in the outcome of nerve regeneration after microsurgical repair using sutures or fibrin tissue adhesive. However, inflammation and granuloma formation were appreciated at the suture site, which presented a focal hindrance to myelin and axonal regeneration. Fibrin glueing is attractive for clinical purposes, since it is simpler and less time consuming than suturing.
设计了一项实验研究，以比较使用10-0显微外科缝线和纤维蛋白粘合剂进行神经吻合的组织学分析。切断Wistar白化大鼠的坐骨神经，并用纤维蛋白粘合剂-Beriplast P（Centeon-Cadila Healthcare公司）或10-0单丝显微缝线进行修复。在术后10、20、30、60和90天进行组织学评估。坐骨神经的功能恢复在两个月时开始，到三个月时接近正常。在任何粘合神经中均未发生残端分离。组织学评估显示，使用缝线或纤维蛋白组织粘合剂进行显微外科修复后，神经再生的结果没有明显差异。然而，在缝线部位观察到炎症和肉芽肿形成，这对髓鞘和轴突再生造成了局部阻碍。纤维蛋白粘合在临床应用中很有吸引力，因为它比缝合更简单、耗时更少。
